Table 1

Correlation between I⁻ scintigraphy and NIS expression

	T₃^a	T₄	TSH μIU/ml	Scintiscan	Thyroid uptake ¹²³I @ 24 h^b	Thyroid uptake ¹³¹I @ 24 h^b	Metastasis	Tissues	NIS expression	Estrogen receptor in index tumor or metastasis	Ongoing therapy
	T₃^a	T₄	TSH μIU/ml	Scintiscan	Thyroid uptake ¹²³I @ 24 h^b	Thyroid uptake ¹³¹I @ 24 h^b	% Uptake of ingested dose	(Index tumor or metastasis)	NIS expression	Estrogen receptor in index tumor or metastasis	Ongoing therapy
1				^99mTcO₄			−	M (soft tissue)	Neg	−	+
2 ^c				^99m TcO ₄			−	M (soft tissue)	Pos	−	+
3				^99mTcO₄			−	I	Neg	+	+
4				^99m TcO ₄			∼1%	M (soft tissue)	Pos	−	−
5				^99mTcO₄			−	I	Neg	+	+
6				^99mTcO₄			−	I	Neg	−	+
7				^99mTcO₄			−	I	Neg	−	+
8				¹²³I			−	I	Neg	+	+
9				¹²³I			−	M (soft tissue)	Neg	+	+
10		X^d	0.3	¹²³ I	0%		−	I	Pos	+	+
11				¹²³I	20.3%		−	I	Neg	+	+
12				¹²³I	48%		−	NA	NA	+	+
13		X	4.2	¹²³I	11%		−	NA	NA	+	+
14	X		0.088	¹²³I	1.4%	2.5% (4 h)^e	2.9%	I	Pos	−	+
	X+		0.031	¹³¹ I		0.22% (24 h)	−	M (lung)	Pos
	MMI					0.048% (48 h)	−
						0.035% (72 h)	−
15	X		0.036	¹²³I	0.9%		−	M (bone)	Neg	−	+
16		X	2.1	¹²³I	Minimal		−	M (lymph node)	Neg	−	−
17	X		0.572	¹²³ I	3.8%		−	I	Pos	−	+
18	X		0.019	¹²³I	2.0%		−	NA	NA	+	+
19	X		0.014	¹²³I	1.4%		−	NA	NA	+	+
20	X		0.007^f	¹²³I	4.6%		−	I	Neg	+	+
21	X		Not done	¹²³I	2.0%		−	I	Neg	−	+
								M (soft tissue)	Neg	−
22	X		0.018	¹²³ I	1.7%		−	I	Pos	−	+
23	X		0.135	¹²³ I	Trace		−	I	Pos	−	−
24	X		0.33	¹²³ I	2.7%		−	I (axillary lymph)	Pos	−	+
25	X		0.054	¹²³I	2.8%		−	M (soft tissue)	Neg	−	+
26	X		0.00	¹²³I	1.99%		−	I (recurrent breast)	Neg	−	+
27	X		0.079	¹²³I	1.26%		−	I (→metastasis)	Neg	+	+
								Contralateral primary	Pos	−	+

Note: Bold designates the NIS-positive cases.
^a T₃, triiodothyronine; T₄, thyroxine; TSH, thyroid-stimulating hormone; NIS, Na⁺/I⁻ symporter; M, metastasis; Neg, negative; Pos, positive; I, index or primary breast cancer; NA, not available; MMI, methimazole.
^b Handheld probe.
^c Bold designates the NIS-positive cases.
^d Primary hypothyroidism.
^e Scintigraphic calculation.
^f Performed 1 week before scan.