Table 2

Performance characteristics of conventional cytology, methylation analysis, and their combination, for the diagnosis of metastatic lymph node

StrategySensitivitySpecificityNPVaPPVOA
Conventional cytology76% (16/21)100% (21/21)81% (21/26)100% (16/16)88% (37/42)
Methylation analysis81% (17/21)67% (14/21)78% (14/18)71% (17/24)74% (31/42)
Combination of conventional cytology and methylation analysis90% (19/21)67% (14/21)87% (14/16)73% (19/26)79% (33/42)
  • a NPV, negative predictive value; PPV, positive predictive value; OA, overall accuracy.