Table 4

Pharmacokinetic parameters

Dose (mg/m2)nAUClast (mg·h/liter)aCmax (mg/liter)Vd (liter)t1/2 (h)AUClast/dose (h/ml)
40121610.75.35133.6
60192734.04.04228.1
8031582 (338)43.5 (1.2)5.53 (1.54)39 (2)10.2 (2.9)
9631987 (553)51.2 (5.8)4.85 (0.77)37 (9)10.8 (3.3)
11552650 (999)73.5 (17.3)4.06 (1.02)40 (19)11.7 (4.2)
13853463 (1131)80.8 (20.8)4.58 (0.96)41 (9)12.8 (5.0)
  • a AUClast, area under the plasma concentration-time curve from the time of dosing to the last observable concentration; Cmax, maximum observed plasma concentration; Vd, volume of distribution; t1/2, terminal half-life.