Table 3

Dose expressions (mg, mg/m2, mg/kg, and AUCa) as predictors of toxicity end points: TI and DLT for selected agents

P values of each expression are reported. Dose expressions in bold were chosen as the expression of the dose for the subsequent analyses on the effect of covariates.

AgentOutcomemgmg/m2mg/kgAUC
PaclitaxelTI 0.0151 0.03700.2124
DLT0.82370.6095 0.5493
EstramustineTI0.0627 0.0484 0.0626
DLT0.31020.255 0.2197
CarboplatinTI0.34820.62810.8771 0.3146
DLT0.43030.34190.3089 0.2937
CisplatinTI<0.0001 <0.0001 <0.0001
DLT0.2874 0.2889 0.3107
DocetaxelTI0.74260.3894 0.2863
DLT0.94850.2870 0.0644
IrinotecanTI0.83850.1276 0.0204
DLT0.98330.3322 0.1831
TomudexTI0.51140.1508 0.0438
DLT0.24400.1489 0.0961
TipifarnibTI0.1891 0.0368 0.1730
DLT0.2005 0.0328 0.0582
  • a AUC, area under the curve; TI, toxicity index; DLT, dose-limiting toxicity.