Table 4

Individual covariates as predictors of toxicity end points, TI,a and DLT

Covariate P values significant at a comparisonwise 5% level are in bold.

CovariateOutcomePaclitaxel (mg)Estramustine (mg/m2)Carboplatin (AUC)Cisplatin (mg/m2)Docetaxel (mg/kg)Irinotecan (mg/kg) + tomudex (mg/kg)Tipifarnib (mg/m2)
Alkaline phosphataseTI0.0790 0.0072 0.2597 0.0334 0.0324 0.0748 0.0187
DLT0.39590.07250.45010.0981 0.0308 0.0209 0.0430
Serum total bilirubinTI0.42840.3750 0.0050 0.2821 0.0001 0.43890.6609
DLT0.20370.10650.07990.19090.14990.28040.3888
AlbuminTI0.0678 0.0010 0.94980.94910.72580.2180 0.0338
DLT0.07000.06350.25900.55560.65820.0525 0.0117
SGOTTI0.2356 0.0039 0.64630.59910.18130.74840.1226
DLT0.8915 0.0333 0.98520.21210.07240.30470.1525
Serum creatinineTI0.74840.52310.68890.78630.9615 0.0290 0.6573
DLT0.40700.40240.85380.62910.94710.12080.5766
Performance statusTI <0.0001 <0.0001 0.76040.20470.25610.23990.1539
DLT0.0811 0.0561 0.83710.25710.19920.23870.1071
Weight lossTI0.06230.11330.88820.12490.0816 0.0434 0.8505
DLT 0.0398 0.08580.34700.11460.4490 0.0231 0.7976
Cigarette smokingTI0.67330.98300.95310.22190.4066 0.0111 0.9465
DLT0.56160.16670.35330.43620.79650.15900.5606
Prior chemotherapyTI0.63300.23470.93450.56970.83150.21550.5675
DLT0.0550.0580.41580.47720.53130.03140.6960
  • a TI, toxicity index; DLT, dose-limiting toxicity; AUC, area under the curve; SGOT, aspartate aminotransferase.