Table 5

Selected “best subset” of covariates for each agent

Estimated COEF,a SEs, and P values

AgentCovariateToxicity indexDLT
COEFSEPCOEFSEP
PaclitaxelDose (mg)−0.001960.00092 0.0341 0.00190.0040.6458
Performance status0.42680.1074 0.0001
Weight loss1.02740.189 0.0182
EstramustineDose (mg/m2)0.0005390.00017 0.0041
Alkaline phosphatase0.0008270.000296 0.0059
Performance status0.62130.1233 0.0001
CarboplatinDose (AUC)0.04360.05080.4060
Serum total bilirubin1.10660.3941 0.0057
CisplatinDose (mg/m2)−0.04020.0068 0.0001
Alkaline phosphatase0.00650.0024 0.0111
DocetaxelDose (mg/kg)0.66480.39450.09971.2571.2060.2850
Alkaline phosphatase0.01610.0075 0.0032
Serum total bilirubin2.74180.6544 0.0001
Irinotecan + tomudexIrinotecan dose (mg/kg)1.5350.3917 0.0006 3.4182.093 0.0439
Tomudex dose (mg/kg)11.577.390.130111.8926.040.6465
Alkaline phosphatase0.006230.00156 0.0005 0.02010.0081 0.0009
Serum creatinine1.830.61 0.006
Cigarette smoking−1.410.33 0.0003 −3.421.52 0.0067
TipifarnibDose (mg/m2)0.00520.0025 0.0495 0.01150.00920.1869
Alkaline phosphatase0.002050.00082 0.0187 0.01830.011 0.0314
Albumin−4.932.3 0.0030
  • a COEF, coefficients; DLT, dose-limiting toxicity; AUC, area under the curve.