Table 2

MRP1 variants identified from one ovarian tumor tissuea

MRP1 variantsSize (kb) of codingSkipped exonsIncluded intronsFrame shift
MRP14.6NoNoNo
MRP1–2kb2.2Exons 12–26, 99 nucleotides of exon 27 in 3′ portionNoNo
MRP1-d54.5Exon 5NoNo
MRP1-d134.4Exon 13NoNo
MRP1-d174.4Exon 17NoNo
MRP1-d4d5b4.3Exons 4 and 5NoNo
MRP1-d16d17b4.3Exons 16 and 17NoYes, premature stop
MRP1-d17d184.2Exons 17 and 18NoNo
MRP1-d17d25b4.3Exons 17 and 25NoYes, premature stop
MRP1-d5d30b4.3Exons 5 and 30NoNo
MRP1-v9b4.1Exons 13, 17 and 18NoNo
MRP1-d2d17b4.2Exons 2 and 17NoNo
MRP1-d18d25b4.397 nucleotides of exon 18 in 5′ portion and exon 25NoYes, premature stop
MRP1-v6b4.8No193 nucleotides of intron 6, 118 nucleotides downstream of exon 6Yes, premature stop
MRP1-v10b4.6Exon 13193 nucleotides of intron 6, 118 nucleotides downstream of exon 6Yes, premature stop
MRP1-v5b4.588 nucleotides of exon 5 in 5′ portionNoYes, premature stop
  • a Sequences of MRP1 splice variants were analyzed with bioinformatics tools at http://workbench.sdsc.edu.

  • b Novel MRP1 splice variants.