Patient no. | Histology | Cohort | Specimen | Sectioning levels | % of reference binding at each level^{a} | Intraspecimen median (range)^{b} | Interspecimen median (range)^{c} | Interspecimen mean (SE)^{d} |
---|---|---|---|---|---|---|---|---|
1 | GIST^{e} | Sarcoma | A | 1, 2, 3, and 4 | 0.3, 0.1, 0.2, and 0.6 | 0.3 (0.5) | 0.2 (0.3) | 0.4 (0.5) |
B | 1, 2, and 3 | 0, 0, and 0.7 | 0.0 (0.7) | |||||
2 | GIST | Sarcoma | A | 1, 2, and 3 | 1.4, 1.4, and 1.1 | 1.4 (0.3) | 1.4 | 1.4 (1.7) |
3 | Ovarian CA | Ovarian | A | 1 and 2 | 6.3 and 4.7 | 5.5 (1.6) | 5.5 (6.2) | 5.1 (2.8) |
B | 1 | 8.3 | 8.3 | |||||
C | 1 and 2 | 1.8 and 2.3 | 2.1 (0.5) | |||||
4 | Ovarian CA | Ovarian | A | 1 | 3.2 | 3.2 | 3.2 (67.5) | 26.2 (11.0) |
B | 1 and 2 | 95.3 and 44.1 | 69.7 (51.2) | |||||
C | 1 and 2 | 2.8 and 1.6 | 2.2 (1.2) | |||||
5 | Colon CA | GI | A | 1 | 6.0 | 6.0 | 6.2 (32.8) | 15.0 (7.5) |
B | 1 and 2 | 22.4 and 54.9 | 38.7 (32.5) | |||||
C | 1 | 6.4 | 6.4 | |||||
D | 1 | 5.9 | 5.9 | |||||
6 | Colon CA | GI | A | 1 | 50.0 | 50.0 | 29.7 (35.9) | 29.2 (10.1) |
B | 1 | 18.4 | 18.4 | |||||
C | 1 and 2 | 8.5 and 19.7 | 14.1 (11.2) | |||||
D | 1 | 40.9 | 40.9 | |||||
7 | Colon CA | GI | A | 1 and 2 | 2.3 and 1.6 | 2.0 (0.7) | 8.6 (15.4) | 8.3 (3.2) |
B | 1 and 2 | 18.7 and 16.0 | 17.4 (2.7) | |||||
C | 1 and 2 | 13.3 and 4.7 | 9.0 (8.6) | |||||
D | 1 and 2 | 2.5 and 14.6 | 8.6 (12.1) | |||||
E | 1 and 2 | 5.1 and 4.5 | 4.8 (0.6) | |||||
8 | Small bowel CA | GI | A^{f} | 1, 2, and 3 | 2.3, 0.2, and 1.3 | 1.3 (2.1) | 1.3 | 1.4 (1.7) |
9 | Appendiceal CA | GI | A | 1 | 0.3 | 0.3 | 0.3 (1.5) | 1.0 (1.3) |
B | 1 | 0.2 | 0.2 | |||||
C | 1 and 2 | 1.6 and 1.7 | 1.7 (0.1) |
a EF5 binding is expressed as a percentage of maximum hypoxia marker binding in tissue from the same patient. Reference binding values were not available for patients 4, 7, and 9. For these patients, the percentage of reference binding was calculated based on the average reference binding level in other patients of the same disease cohort.
b Median and range (largest-smallest) of values for each specimen.
c Median and range (largest-smallest) of median values of specimens for each patient.
d The model-based mean and SE of specimens for each patient.
e GIST, gastrointestinal stromal tumor; CA, carcinoma.
f An additional three specimens from patient 8 were found by histological analysis to contain no tumor and are thus not included in these data.