Table 3

Survival significance of clinical variables and matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) expression in 83 patients with classical medulloblastoma (cMB) and clinical variables in 18 patients with desmoplastic MB (dMB)

Variable (n = cMB/dMB)Classical MB, n (%)Survival (P)aDesmoplastic MB, n (%)
Sex (83/18)
 Female32 (39)5 (28)
 Male51 (61)NSb13 (72)
Age (83/18)
 <3 years15 (18)6 (33)
 ≥3 years68 (82)<0.0512 (67)
M-stage (50/10)c
 M040 (80)9 (91)
 M1–M310 (20)<0.051 (9)
Surgical resection (71/16)c
 Gross total45 (63)13 (81)
 Near or subtotal26 (37)NS3 (19)
Therapy (66/15)c
 Radio- or chemotherapy12 (18)6 (40)
 Radio- and chemotherapy54 (82)<0.0019 (60)
MMP-2 (83/18)
 −52 (63)3 (17)
 +31 (37)NS15 (83)
MMP-9 (83/18)
 −21 (25)3 (17)
 +62 (75)NS15 (83)
MT1-MMP (83/18)
 −21 (25)3 (17)
 +62 (75)NS15 (83)
MT2-MMP (83/18)
 −20 (24)0
 +63 (76)NS18 (100)
Sum MMP-9 + MT1-MMP + MT2-MMP
 ≤345 (54)8 (44)
 >338 (46)<0.0510 (56)
TIMP-1 (83/18)
 −60 (72)18 (100)
 +23 (28)NS0
TIMP-2 (83/18)
 −49 (59)3 (17)
 +34 (41)NS15 (83)
TIMP-3 (83/18)
 −44 (33)12 (67)
 +56 (67)NS6 (33)
  • a Survival analysis (log-rank test) for patients with classical medulloblastoma. Note: This analysis could not be performed on desmoplastic MB because of the low number of cases.

  • b NS, not significant.

  • c These variables were not known for all patients.