Table 3

Her-2/neu testing by immunohistochemistry in androgen-sensitive, (AS)/primary prostate cancer and in androgen-independent, (AI)/metastasic lesion and by fluorescence in situ hybridization (FISH) in AI/metastasic lesion of 15 patients

CaseAS/primary prostate tumorAI/metastasic lesionAssay for Her-2/neu gene amplification by FISH
Mached pairs
11+2+Negative
21+1+Negative
32+2+Negative
41+2+Negative
51+3+Negative
62+2+Negative
71+2+Negative
81+2+Negative
AI specimens
92+Negative
102+Negative
AS specimens
111+Unknown
121+Unknown
131+Unknown
141+Unknown
152+Unknown
Total3/139/1010/10