Table 2

List of tumor markers in neuroblastoma that were identified by the systematic review together with the number of papers overall and within each clinical area

Tumor MarkerOverallScreeningDiagnosisPrognosisMonitoring
MYCN20171481519
VMA12544784518
HVA10538643516
DNA index/ploidy/diploidy/triploidy/aneuploid/hyperdiploidy56537441
Chromosome 1p or chromosome 1p3647434401
Ferritin or isoferritin49336335
NSE45233289
LDH32122264
Dopamine24222104
TrkA (nerve growth factor receptor)25016160
Adrenaline/epinephrine1501554
Multidrug resistance/associated protein/p-glycoprotein1607160
Nonadrenaline/noradrenaline/norepinephrine1301352
CD44100780
Neuropeptide Y1201090
Tyrosine hydroxylase1201133
Chromosome 17q110980
Ha-ras/P21/H-ras/c-ha-ras110861
Telomerase/Telomeric repeats110670
Chromosome 14q80670
GD2 ganglioside80752
S10071550
Chromosome 11q60561
Low affinity nerve growth receptor (LNGFR)60360
Metanephrine60611
TrkC60350
3-methoxy-4-hydroxyphenyl glycol51310
4-hydroxy-3-methoxymandelic acid50512
Dihydroxyphenylalanine51513
Dopamine β hydroxylase50322
Proliferating cell nuclear antigen/proliferation index/Ki67/KiS5 protein50540