Table 4

Common toxicities

Toxicity% of total patients% of patients per IL-12 dose level (grade)Category of adverse event
30 (n = 3)100 (n = 3)300 (n = 6)500 (n = 3)
Arthralgia2733 (2)33 (2)17 (3*)33 (2)* Disease-related, resolved
Dyspnea6066 (2,4*)33 (2)50 (2)100 (2)* Disease-related
Fatigue93100 (2,4*)66 (2)100 (2,3*)100 (2)* Disease-related
Hemoglobin6033 (2)66 (2)50 (2)100 (2)
Leukocytes4033 (2)33 (2)50 (2,3)33 (3)
Lymphopenia6666 (2,3)66 (2,3)66 (2,3)66 (2)
Polymorphonuclear leukocytes/granulocytes4733 (2)33 (3)66 (2,3)33 (3)