Table 4

Docetaxel pharmacokinetic parameters

Dose mg/m2No. of patientsCmax ng/mLAUC ng/mL·hCl L/h/m2t1/2 hVss L/m2
6052140 ± 11711999 ± 85935.4 ± 17.29.91 ± 7.5204 ± 155
(524–3730)(943–3280)(18.3–63.7)(3.19–22.7)(62.8–461)
5061688 ± 8372015 ± 70528.1 ± 11.811.9 ± 5.52247 ± 181
(455–2629)(1017–2785)(18.0–49.2)(7.74–22.6)(137–604)
  • NOTE. Values represent the mean value ± SD with range in parentheses.

  • Abbreviations: Cmax, peak plasma concentration; AUC, area under the plasma concentration-time curve; Cl, clearance; t1/2, terminal half-life; Vss, volume of distribution at steady state.