Table 5

Pharmacokinetic parameters for 72-hour infusion of flavopiridol

Patient no.Dose mg/m2/dCss μmol/LCss/dose μmol/LAUC(0-infinity) μmol/L·hAUC(adjusted) μmol/L·hCl L/h/m2
1500.410.00830.050.2011.5
2500.400.00826.690.1812.8
Mean500.410.00828.370.1912.1
3280.180.00611.990.1415.6
4280.120.0048.130.1023.6
5280.300.01123.970.298.0
Mean280.200.00714.700.1715.7
Median280.180.00611.990.1415.6
  • Abbreviations: Css, concentration at steady state; AUC(0-infinity), area under the plasma concentration-time curve from time 0 to infinity; Cl, clearance.