Table 6

Pharmacokinetic parameters for 1-hour infusion flavopiridol

Patient no.Dose mg/m2Cmax μmol/LCmax/dose μmol/LAUC(0-infinity) μmol/L·hAUC(adjusted) μmol/L·hCl L/h/m2
6261.710.0663.310.1317.6
7261.740.0675.550.2110.6
8260.750.0291.970.0830.3
Mean261.400.0543.610.1419.5
Median261.710.0663.310.1317.6
9342.920.0869.770.298.0
10200.970.0491.990.1022.7
11201.290.0652.850.1415.6
Mean201.130.0572.420.1219.1
  • Abbreviations: Cmax, peak plasma concentration; AUC(0-infinity), area under the plasma concentration-time curve from time 0 to infinity; Cl, clearance.