Table 1

Concentration of I3C in plasma and tissues of female CD-1 mice that received an oral dose of I3C (250 mg/kg) by the oral route

Time (h)I3C concentration (μg/ml or μg/g tissue)
PlasmaLiverKidneyLungHeartBrain
0.254.13 ± 1.3524.53 ± 5.4816.95 ± 10.625.27 ± 2.245.27 ± 1.182.74 ± 0.89
0.52.21 ± 0.202.60 ± 0.393.73 ± 0.412.07 ± 1.252.84 ± 1.172.10 ± 0.22
0.750.12 ± 0.050.17 ± 0.130.35 ± 0.180.52 ± 0.430.56 ± 0.29nd
1ndndndndndnd
  • NOTE. Results are expressed as mean ± SD of four animals.

  • Abbreviations: I3C, indole-3-carbinol; nd, not detected or the observed concentration was below the limit of quantification of the analytical method (0.05 μg/mL plasma, 0.1 μg/g tissue).