Table 1

Treatment schema

Induction
 Vincristine 1.5 mg/m2 (2 mg maximum) i.v.Days 0, 7, 14, 21
 Dexamethasone 10 mg/m2/day p.o.Days 0–6, 14–20
 Idarubicin 10 mg/m2Days 0–2
 Pegaspargase 2500 IU/m2 i.m.Days 2, 9, 16, 23
 Intrathecal cytarabine, methotrexate, hydrocortisone doses adjusted by ageDays 0, 14, 28 (and 7, 21 if CNS positive at relapse)
Intensification
 Vincristine 1.5 mg/m2 (2 mg maximum) i.v.Days 0, 7
 Dexamethasone 10 mg/m2/day p.o.Days 0–4
 Thioguanine 100 mg/m2/day p.o.Days 0–4
 Methotrexate 1 g/m2 i.v. over 36 h with leucovorin rescue starting at hour 48Days 0, 1
 Cytarabine 100 mg/m2/day i.v.Days 2–4
 Pegaspargase 2500 IU/m2 i.m.Day 7
 Intrathecal cytarabine, methotrexate, hydrocortisone doses adjusted by ageDays 0, 21 (and 7, 14 if CNS negative at relapse)
 Etoposide 100 mg/m2 i.v.Days 21–25
 Ifosfamide 1800 mg/m2 i.v. with MESNADays 21–25
  • Abbreviations: i.v., intravenously; p.o., orally; i.m., intramuscularly; MESNA, 2-mercaptoethane sulfonic acid.