Table 3

Serum PEG-ASNase, serum amino acids, and CSF amino acids during induction and intensification

Pharmacokinetic valueInductionIntensification
Day 0Day 7Day 14Day 21Day 28Day 0Day 7Day 14Day 21Day 28
Median PEG-ASNase, IU/ml0.000.810.841.200.890.010.000.530.200
 >0.03 IU/ml2/2622/2322/2219/2020/226/147/2018/1813/154/12
 >0.1 IU/ml1/2622/2322/2219/2020/226/146/2017/1812/153/12
Median serum Asn, μm28.12.02.83.63.02.82.14.01.42.0
 <3 μm3/2314/2111/218/169/197/1210/188/176/117/10
Median CSF Asn, μm4.52.81.31.10.51.71.01.11.2ND
 <3 μm8/256/1016/246/815/208/129/109/118/13
Median serum Gln, μm48893110767936016810146176
 <100 μm1/2310/219/219/169/193/117/187/176/114/10
Median CSF Gln, μm613875590672597770629592530ND
 <100 μm0/240/90/210/70/180/120/110/110/13
PEG-ASNase Ab ratio ≥1.51/250/231/221/201/212/141/201/181/151/10
  • Abbreviations: CSF, cerebrospinal fluid, ND, not done, Gln, glutamine, Ab, antibody.