Table 1

Aberrant promoter methylation distribution in sporadic breast cancer

CasesESR1CDH1TRβ 1GSTP1CCND2BRCA1RARβ 2APCp16HIC1
High methylation
9TMPMPMPMPMPUPUPMPMPMP
18TMPMPMPMPUPMPUPMPMPMP
14TMPMPMPUPUPUPMPMPMPMP
17TMPMPMPUPUPUPUPUPUPMP
11TMPMPMPUPUPUPUPUPUPMP
30TMPMPMPUPMPUPUPUPUPUP
27TMPMPMPUPMPUPMPUPMPUP
29TMPMPUPUPMPUPMPUPUPUP
B41TMPMPUPUPMPUPUPUPUPMP
B40TMPMPUPMPUPUPUPUPUPUP
B58TMPMPUPUPUPUPUPMPUPMP
B66TMPMPUPUPUPUPUPMPUPMP
26TMPMPUPUPUPUPUPMPUPUP
B42TMPMPUPUPUPMPUPUPUPUP
B51TMPMPUPUPUPMPUPUPMPMP
B30TMPUPMPUPUPMPUPUPUPUP
B45TMPUPMPUPUPUPUPUPUPMP
B37TMPUPMPUPUPUPUPUPUPMP
8TMPUPMPMPUPUPUPMPUPMP
B32TMPUPUPUPMPUPMPUPMPUP
B35TMPUPUPUPUPUPMPUPUPMP
B39TMPUPUPUPUPUPMPUPUPMP
B67TMPUPUPMPUPUPUPUPUPMP
19TUPMPUPUPUPUPUPMPUPMP
B55TUPUPMPUPUPMPUPMPMPUP
22TUPUPUPMPUPUPUPUPMPMP
B60TUPUPUPUPUPMPUPMPUPMP
B57TUPUPUPUPUPUPMPMPMPMP
B24TUPUPUPUPUPUPMPMPUPMP
Moderate methylation
B46TMPUPUPMPUPUPUPUPUPUP
28TMPMPUPUPUPUPUPUPUPUP
B44TUPMPUPUPUPUPUPUPUPMP
3TUPMPUPUPUPUPUPUPUPMP
23TUPMPMPUPUPUPUPUPUPUP
B38TUPUPMPUPUPUPUPUPUPMP
B65TUPUPMPUPUPMPUPUPUPUP
B48TUPUPUPUPUPMPUPUPUPMP
20TUPUPUPUPUPUPUPUPUPMP
25TUPUPUPUPUPUPMPMPUPUP
B64TUPUPUPUPUPUPMPMPUPUP
Low methylation
21TUPMPUPUPUPUPUPUPUPUP
B61TUPUPUPUPUPMPUPUPUPUP
B59TUPUPUPUPUPUPMPUPUPUP
33TUPUPUPUPUPUPUPMPUPUP
B63TUPUPUPUPUPUPUPUPMPUP
B27TUPUPUPUPUPUPUPUPUPMP
24TUPUPUPUPUPUPUPUPUPUP
5TUPUPUPUPUPUPUPUPUPUP
10TUPUPUPUPUPUPUPUPUPUP
B43TUPUPUPUPUPUPUPUPUPUP
B50TUPUPUPUPUPUPUPUPUPUP
34TUPUPUPUPUPUPUPUPUPUP
36TUPUPUPUPUPUPUPUPUPUP
37TUPUPUPUPUPUPUPUPUPUP
Unmethylated29333947484543394428
Methylated25211576911151026
%*46%39%28%13%11%17%20%28%18%48%
  • Abbreviations: MP, methylated promoter; UP, unmethylated promoter.

  • * Percentage of tumors that carry methylation at the particular gene.