Table 3

Associations of patient and disease characteristics with survival

ParameterCategoryNo.2-yr % survival4-yr % survivalP (log rank)
Age (years)<6033782610.60
≥601288561
SplenomegalyNo33789700.0001
Yes576349
Hemoglobin (g/dl)<1220778560.06
≥122518765
WBC (×109/l)≤5038584640.003
>50737948
Platelets (×109/l)≤4503498666<0.0001
>4501077542
% peripheral basophils<740285640.0003
≥7506731
Peripheral blastsNo3668765<0.0001
Yes866643
% marrow basophils<433486670.003
≥4738050
% marrow blasts<53708768<0.0001
≥5386226
Cytogenetic clonal evolutionNo36487660.05
Yes456655
Sokal risk (20)Low13982600.01
Intermediate1008358
High466741
Duration of chronic phase (months)<126682570.20
12–352078564
≥361928158
IFN failureHematologic10477440.003
Cytogenetic1988668
Intolerance1638365
% Philadelphia + pretreatment<907794840.005
≥903298360
Study groupStudy group26193<0.0001
Historical group2047144