Histomorphometric measures
| Group | BV (%) | Md.V (%) | Tb.N (mm−1) | Tb.Sp (μm) | Tb.Th (μm) | OV (%) | OS (%) | O.Th (μm) | ES (%) |
|---|---|---|---|---|---|---|---|---|---|
| Intact | 16.93 ± 0.23 | 16.88 ± 0.24 | 2.83 ± 0.07 | 294.9 ± 8.0 | 60.02 ± 1.06 | 0.28 ± 0.05 | 3.85 ± 0.60 | 2.18 ± 0.13* | 1.05 ± 0.25† |
| OVX | 10.49 ± 0.78‡ | 10.11 ± 0.75‡ | 1.80 ± 0.09‡ | 502.3 ± 27.2‡ | 58.03 ± 2.29 | 3.52 ± 0.64‡ | 20.86 ± 2.62‡ | 4.89 ± 0.58 | 2.73 ± 0.63 |
| OVX + EXE (20 mg/kg) | 13.44 ± 0.67 | 13.52 ± 0.59 | 2.12 ± 0.10 | 411.8 ± 19.6 | 64.27 ± 1.33 | 0.77 ± 0.11 | 6.83 ± 0.86 | 4.03 ± 0.61 | 1.72 ± 0.61 |
| OVX + EXE (50 mg/kg) | 17.92 ± 0.90 | 17.84 ± 0.90 | 3.00 ± 0.17 | 277.8 ± 18.8 | 59.83 ± 0.73 | 0.43 ± 0.05 | 4.09 ± 0.62 | 3.32 ± 0.26* | 1.11 ± 0.27† |
| OVX + EXE (100 mg/kg) | 17.09 ± 1.11 | 17.04 ± 1.10 | 2.89 ± 0.14 | 289.7 ± 17.4 | 59.09 ± 2.69 | 0.31 ± 0.02 | 3.58 ± 0.33 | 2.81 ± 0.47* | 1.02 ± 0.24† |
| OVX +17-H-EXE (20 mg/kg) | 17.64 ± 0.92 | 17.56 ± 0.91 | 2.69 ± 0.16 | 311.72 ± 21.1 | 66.21 ± 3.92 | 0.40 ± 0.08 | 4.09 ± 0.51 | 3.27 ± 0.38* | 1.14 ± 0.21† |
NOTE. Data are mean ± SE (n = 5).
Abbreviations: BV, bone volume; Md.V, mineralized trabecular bone volume; Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness; OV, osteoid volume; OS, osteoid surface; O.Th, osteoid thickness; ES, eroded surface.
* P < 0.005 versus OVX rats.
† P < 0.05 versus OVX rats.
‡ Significant difference from all other groups (P< 0.001).