Table 1

Demographics of study population by p53 genotype

GGGCCCTotal
Cancer status
 Colorectal cancer patients29 (61.7%)17 (36.2%)1 (2.1%)47 (51.1%)
 Unaffected MMR mutation carriers28 (62.2%)11 (24.4%)6 (13.3%)45 (48.9%)
Gender
 Male24 (55.8%)15 (34.9%)4 (9.3%)43 (46.7%)
 Female33 (61.9%)13 (26.5%)3 (6.1%)49 (53.3%)
MMR gene mutated
MLH125 (62.5%)10 (25.0%)5 (12.5%)40 (43.5%)
MSH232 (61.5%)18 (34.6%)2 (3.9%)52 (56.5%)
MMR gene mutation type
 Truncation/deletion38 (61.3%)20 (32.3%)4 (6.5%)62 (67.4%)
 Missense19 (63.3%)8 (26.7%)3 (10.0%)30 (32.6%)
 All subjects57 (62.0%)28 (30.4%)7 (7.6%)92 (100%)
Allele frequency
G allele0.772
C allele0.228
Age of onset for colorectal cancer (yrs)
 Time at risk259011023294021
 Incidence rate0.01120.01540.00300.0117
 Range26–8921–7130–7021–89
 75% of subjects cancer-free*393635
 50% of subjects cancer-free*53406342
 25% of subjects cancer-free*705052
  • NOTE. All study subjects were Caucasian.

  • * The age of onset values were determined from Kaplan-Meier estimates, with the median age of onset defined as the age at which 50% of the population is cancer-free.

  • Only one of seven homozygotes for the polymorphic allele had colorectal cancer, at 63 years of age.