Table 6

Genes differentially expressed in A431 cells treated with gefitinib or cetuximab

Gene symbolGefitinib foldCetuximab foldDescription
Cell cycle
MCM5−1.771.28 Minichromosome maintenance deficient 5, cell division cycle 46
PPP1CC1.19−1.57 Protein phosphatase 1, catalytic subunit, γ isoform
Cell death
CARD12−1.57−2.42 Caspase recruitment domain family, member 12
Transcription related
E2F5−1.28−1.66 E2F transcription factor 5, p130-binding
EIF4A21.84−1.14 Eukaryotic translation initiation factor 4A, isoform 2
CRSP6−1.52−2.32 Cofactor required for Sp1 transcriptional activation, subunit 6,77kDa
TRAF3−1.43−1.91 TNF receptor-associated factor 3
TP53BPL−1.22−1.83 Tumor protein p53-binding protein
HOXC10−2.59−1.32 Homeobox protein Hox-C10
HOXD8−1.691.25 Homeobox protein Hox-D8
ZNFN1A1−1.921.29 Zinc finger protein, subfamily 1A, 1 (Ikaros)
ZNF212−1.081.58 Zinc finger protein 212
RRN3−1.10−1.71 ribosomal DNA (rDNA) transcription
Cell proliferation/differentiation
EMS1−1.491.39 Ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
CDK7−1.02−1.65 Cyclin-dependent kinase 7
SMARCA5−1.70−2.24 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
AMY−1.481.74 Neuroblastoma (nerve tissue) protein
PTPN6−1.751.26 Protein tyrosine phosphatase, non-receptor type 6
DNA repair
RECQL−1.45−2.50 RecQ protein-like (DNA helicase Q1-like)
TDG−1.48−1.91 Thymine-DNA glycosylase
Oncogene
NET1−1.48−2.67 Neuroepithelial cell transforming gene 1
Secreted protein
PLAU−1.32−2.40 Plasminogen activator, urokinase
Protein biosynthesis
PRKR−2.42−1.46 Protein kinase, interferon-inducible double stranded RNA dependent
PSMD10−1.25−1.89 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSMC6−1.76−2.45 Proteasome (prosome, macropain) 26S subunit, ATPase, 6
Cytoskeleton
TLN11.041.95 Talin 1
MFAP11.04−1.56 Microfibrillar-associated protein 1
Extracellular matrix
COL4A11.562.07 Collagen, type IV, alpha 1
Cell signaling
PIK3CD−1.351.50 Phosphoinositide-3-kinase, catalytic, δ polypeptide
NTRK2−1.441.45 Neurotrophic tyrosine kinase, receptor, type 2
JAK1−1.431.28 Janus kinase 1 (a protein tyrosine kinase)
Immune response
IGHG3−1.491.22 Immunoglobulin heavy constant γ 3 (G3m marker)
CSF1−1.421.35 Colony stimulating factor 1 (macrophage)
Metabolism
ENO1−2.051.25 Enolase 1, (α)
GSTP11.021.64 Glutathione S-transferase π
OAT−1.68−2.19 Ornithine aminotransferase (gyrate atrophy)
Angiogenesis
ENG2.249.63 Endoglin (Osler-Rendu-Weber syndrome 1)
Basic cellular function/ Miscellaneous
ITM2B−1.17−1.84 Integral membrane protein 2B
CAPZA2−1.39−2.22 Capping protein (actin filament) muscle Z-line, α 2
HSPB2−1.341.55 Heat shock 27kDa protein 2
CLU−1.03−1.56 Clusterin (complement lysis inhibitor, SP-40, 40, sulfated glycoprotein 2)
SOX22−1.411.25 SOX-12 protein (SOX-22 protein)
DKFZP564O0463−1.59−2.92 HSPC064 protein
ESTs−1.68−1.16 EST, AI247680
ESTs−1.62−1.01 EST, Moderately similar to chemokine receptor D6 [H. sapiens], g4665651
  • Note. This table includes the genes that were differentially expressed in A431 cells treated with gefitinib or cetuximab. The genes were considered differentially expressed if they had an unadjusted P value of ≤0.03 (t test).