Table 4

MIB-1, p53, and Bcl-2 expression* (mean ± SD) in bronchial biopsies at baseline and after intervention for 6 months

No. of biopsiesBaseline (%)6 months (%)
MIB-1
 Pulmicort14228 ± 1521 ± 17
 Placebo18728 ± 1421 ± 15
p53
 Pulmicort13142 ± 2635 ± 26
 Placebo16337 ± 2740 ± 27
BCL2
 Pulmicort10919 ± 1516 ± 13
 Placebo13920 ± 1324 ± 15
  • * Percentage of positively stained cells per 200 cells.

  • Percentage of positively stained cells decreased after Pulmicort and increased after placebo. The difference in the change between the two groups was significant (P = 0.01, t test).

  • Percentage of positively stained cells decreased after Pulmicort (P = 0.042, paired t test) and increased after placebo (P = 0.011, paired t test). The difference in the change between the two arms was statistically significant (P = 0.001).