Table 1

Frequency of overexpression of cyclins and CDKs in pancreatic intraepithelial neoplasia—duct cell carcinoma sequence

No. of lesions studiedCCND1CCND3CCNACCNECDK4/6CDK2
Normal27–29000000
PanIN-1A15–18031%0000
PanIN-1B36–40055%15%011%7%
PanIN-223–3022%93%56%22%48%33%
PanIN-315–1911%100%100%24%53%53%
ADC37–3827%92%87%71%76%61%
  • Abbreviations: CCN, cyclin; PanIN, intraepithelial neoplasia; ADC, adenocarcinoma.