Table 1

List of the significantly dysregulated genes in IBCs relative to non-IBCs

GenesGene definitionGene characterisationNon-IBC (n = 22)IBC (n = 36)P*ROC-AUC
JUN Jun oncogeneTranscription factor1.0 (0.2–10.4)†8.3 (0.8–230.7)<10−60.908
EGR1 Early growth response 1 (Krox-24)Transcription factor1.0 (0.1–5.2)13.8 (0.3–625.1)<10−60.896
DUSP1 Dual specificity phosphatase 1 (CL100, MKP-1)Signaling transduction1.0 (0.2–4.8)13.7 (0.6–303.0)<10−60.896
JUNB Jun B oncogeneTranscription factor1.0 (0.1–4.2)6.7 (0.6–47.9)<10−60.893
FOS Fos oncogeneTranscription factor1.0 (0.3–15.9)30.1 (0.4–1051.5)<10−60.886
FOSB Fos B oncogeneTranscription factor1.0 (0.1–19.7)40.5 (0.2–1580.4)0.0000020.876
VEGF Vascular endothelial growth factorAngiogenesis1.0 (0.1–2.4)2.9 (0.5–13.8)0.0000080.852
DTR/HB-EGF Diphtheria toxin receptor (heparin-binding EGF-like growth factor)Growth factor1.0 (0.3–4.9)4.7 (0.4–56.4)0.000040.824
TBXA2R Thromboxane A2 receptorAngiogenesis1.0 (0.4–4.0)4.4 (1.2–22.2)0.000040.824
PTGS2/COX2 Prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2)Angiogenesis1.0 (0.2–22.9)10.7 (0.2–256.3)0.000040.824
IGFBP7 Insulin-like growth factor binding protein 7 (IGFBP-rP1/MAC25)Growth factor1.0 (0.1–2.8)3.1 (0.3–23.1)0.000120.803
IL6 Interleukin 6Growth factor1.0 (0.2–20.6)9.3 (0.4–93.11)0.000200.793
NOS3 Nitric oxide synthase 3, endothelial (ENOS)Oxidative stress1.0 (0.2–3.6)3.5 (0.6–9.6)0.000290.785
MAP3K8/COT Mitogen-activated protein kinase kinase kinase 8Signaling transduction1.0 (0.3–3.0)2.7 (0.1–11.6)0.000680.768
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1Signaling transduction1.0 (0.1–108.0)6.6 (0.7–183.5)0.00120.755
KAI1 Kangai 1 (CD82 antigen)Cell motility1.0 (0.2–4.1)3.4 (1.0–10.5)0.00140.752
THBD ThrombomodulinAngiogenesis1.0 (0.2–4.6)3.6 (0.5–23.6)0.00140.751
PPARGC1 Peroxisome proliferative activated receptor, gamma, coactivator 1 (PGC1)Transcription factor coactivator1.0 (0.0–14.0)3.0 (0.4–156.6)0.00240.739
ANGPT2 Angiopoietin 2Angiogenesis1.0 (0.2–4.7)3.0 (0.3–10.7)0.00240.739
EREG EpiregulinGrowth factor1.0 (0.0–173.2)16.1 (0.2–10744.5)0.00370.729
TNFRSF10A Tumor necrosis factor receptor superfamily, member 10a (TRAILR1, DR4)Apoptosis1.0 (0.4–2.3)2.7 (0.2–17.9)0.00430.725
ROBO2 Roundabout homolog 2Growth factor receptor1.0 (0.0–771.6)14.8 (0.0–1521.1)0.00730.711
CCL3/MIP1A Chemokine (C-C motif) ligand 3Growth factor1.0 (0.1–5.6)2.0 (0.2–31.2)0.0190.684
MYCN N-myc oncogeneTranscription factor1.0 (0.1–41.8)3.1 (0.2–144.4)0.0210.682
CCL5/RANTES Chemokine (C-C motif) ligand 5Growth factor1.0 (0.1–5.0)3.2 (0.1–33.1)0.0290.672
SNAIL1 Snail homolog 1Transcription factor1.0 (0.3–5.3)2.2 (0.5–7.3)0.0430.660
H19 H19, imprinted maternally expressed untranslated mRNADevelopment1.0 (0.1–13.4)6.4 (0.1–58.6)0.0460.657
MKI67 Proliferation-related Ki-67 antigenCell cycle regulation1.0 (0.1–3.7)1.6 (0.2–21.2)NS (0.07)0.644
ESR1/ERαEstrogen receptor 1 (α)Nuclear receptor1.0 (0.0–21.1)0.4 (0.0–21.3)NS (0.18)0.606
  • * Kruskal-Wallis test.

  • ‡ Median (range) of gene mRNA levels.