Table 1

Antitumor activity of E2, E4, and E8 in a s.c. Karpas-299 xenograft model

ScheduleAntibody-drug conjugateDose (mg/kg)Complete regressionsCures
q4d×4E20.50/100/10
1.010/1010/10
E40.251/101/10
0.505/103/10
E80.250/100/10
0.506/106/10
×1E20.50/60/6
1.04/64/6
E40.51/61/6
1.06/65/6*
E80.52/62/6
1.05/65/6
  • * One mouse with a cure was found dead on day 72 with no sign of tumor mass.