Table 2

Pharmacokinetic parameters of cAC10 and cAC10 antibody-drug conjugates in SCID mice at a dose of 10 mg/kg (± SD)

NameHalf-time (days)Area under the curve (μg-day/mL)Clearance (mL/day/kg)Volume of distribution (mL/kg)
cAC1016.7 (0.2)2638 (64)3.8 (0.1)91 (3.2)
E216.9 (1.7)2313 (282)4.4 (0.6)107 (14)
E414.0 (2.5)1689 (187)6.0 (0.6)122 (30)
E814.9 (1.8)520 (21)19.2 (0.8)414 (66)