Table 4

ELISA of human ovarian CCA that was growing subcutaneously in nude mice

Dosage of IFN-αCon1Serum level (pg/ml)Levels in the tumor lysate (pg/ml)
BFGFIL-8VEGFBFGFIL-8VEGF
KOC-5C
 Saline (control)77.5 ± 32.017.0 ± 4.0236.9 ± 38.0
 1× 104 units46.7 ± 24.015.5 ± 4.0272.5 ± 43.0
 1× 105 units74.9 ± 45.030.2 ± 13.0288.8 ± 31.0
 1× 106 units73.4 ± 20.028.8 ± 13.0205.1 ± 39.0
KOC-7C
 Saline (control)81.3 ± 14.023.2 ± 4.0229.0 ± 50.0341.3 ± 123.01348.4 ± 1722.0858.3 ± 272.0
 1× 104 units34.5 ± 9.0 22.0 ± 3.0231.1 ± 39.0
 1× 105 units47.4 ± 22.0*17.1 ± 4.0*262.3 ± 28.0
 1× 106 units31.6 ± 11.015.0 ± 5.0215.5 ± 24.0277.3 ± 122.0120.7 ± 58.0565.1 ± 138.0*
  • NOTE. The KOC-5C or KOC-7C cells (1 × 107) were subcutaneously transplanted into nude mice. From the 18th day after the transplantation, mice in each group received IFN-αCon1 or saline for 14 consecutive days. All mice were sacrificed on the 32nd day.

  • * P < 0.05, versuscontrol.

  • P< 0.01, versuscontrol.

  • P< 0.001, versus control.