Table 4

Maintenance dose toxicity summary

Dose levelGrade of nauseaNo.Grade of vomitingNo.Grade of diarrheaNo.Grade of fatigueNo.Other
11200011Joint aches, anorexia
23
212001216Arthralgias, anorexia, elevated liver function tests
2221
3181314114′Gout,′ dehydration, myalgia, anorexia
21222322
3*3*
4181514112Leg, foot pain, anorexia, dehydration
232232
3131
512131115Gastrointestinal bleed, anorexia, elevated liver function tests
212122
31
  • * Dose-limiting toxicity.