Table 1

Effect of 10% FS and TAM on the body weight, food intake, and relative uterine weight *

Total food intake (6 weeks; g/mouse)Body weight (g)Uterine weight (mg/g body weight)
Experiment 1 (no E2 pellet implant)Week 7Week 13Week 14
 +E2 74.1 ± 2.4a18.0 ± 0.3a17.7 ± 0.3a5.59 ± 1.21a
 −E299.7 ± 3.9b18.4 ± 0.3a19.3 ± 0.4a,b1.13 ± 0.10b
 FS−E2104.2 ± 4.4b17.6 ± 0.5a19.9 ± 0.2b1.18 ± 0.10b
 TAM−E294.5 ± 2.9b17.3 ± 0.4a18.7 ± 0.4a,b1.57 ± 0.12c
 FS+TAM−E2109.0 ± 4.8b17.7 ± 0.3a19.2 ± 0.4a,b1.46 ± 0.15b,c
Experiment 2 (with E2 pellet implant)Week 6Week 12Week 12
 +E297.9 ± 1.0a18.3 ± 0.3a19.2 ± 0.6a2.80 ± 0.65a
 −E2107.3 ± 3.4a17.9 ± 0.3a20.5 ± 0.5a0.95 ± 0.10b
 FS+E295.4 ± 3.5a18.5 ± 0.2a19.2 ± 0.4a2.95 ± 0.17a
 TAM+E296.6 ± 9.8a18.3 ± 0.3a19.0 ± 0.6a3.25 ± 0.48a
 FS+TAM+E292.0 ± 1.8a18.4 ± 0.4a18.4 ± 0.5a3.26 ± 0.72a
  • * Data are means ± SEM. Means with different superscripts within the same column and experiment are significantly different at P < 0.05 (one-way ANOVA followed by Tukey test).

  • Mice were sacrificed at week 13, whereas all other groups were sacrificed at week 14.