Table 1

Summary of univariate analysis and multivariate Cox regression analysis of MB survival data

VariableUnivariate analysisFull multivariate model *
P (log-rank test)HR (95% CI)P (Wald test)HR (95% CI)
Primary radiotherapy (yes vs. no)0.0120.45 (0.24–0.85)
Metastatic disease <0.00013.23 (1.77–5.88)0.0082.46 (1.27–4.78)
Extent of surgery 0.0880.76 (0.56–1.04)0.380.86 (0.61–1.21)
Age at diagnosis (y)0.0830.93 (0.86–1.01)0.230.94 (0.85–1.04)
p53 §<0.00014.01 (2.01–8.01)0.0162.88 (1.22–6.84)
ErbB2 §0.0032.58 (1.35–4.94)0.261.60 (0.70–3.66)
TrkC §0.0760.54 (0.27–1.10)0.110.54 (0.26–1.14)
MYC §0.731.14 (0.55–2.38)0.401.41 (0.63–3.17)
TUNEL §0.551.22 (0.64–2.34)0.741.15 (0.50–2.64)
Anaplasia (yes vs. no)0.750.83 (0.26–2.67)0.591.43 (0.39–5.20)
MIB1 (% expressed)0.561.006 (0.99–1.03)0.800.997 (0.97–1.02)
Chemotherapy (yes vs. no)0.361.73 (0.53–5.60)0.701.28 (0.36–4.55)
  • * Stratified by primary radiotherapy; controlled by stratification.

  • Present at diagnosis versus absent at diagnosis.

  • Treated as linear in analysis: 1, biopsy only; 2, subtotal resection < 95%; 3, radical subtotal resection; and 4, gross total resection.

  • § Present versus absent by immunohistochemistry.