Table 1

Hybrid model parameters for temozolomide in rats

ParametersControlTNP-470
K01 (minutes−1)0.0157 (7.6) *0.0183 (10.1)
K12 (minutes−1)0.086 (25.6)0.0803 (22.6)
K21 (minutes−1)0.0488 (43.7)0.0737 (39.8)
V1 (mL)553.1 (7.5)479.7 (10.0)
K34 (minutes−1)0.173 (13.9)0.0475 (8.22)
K43 (minutes−1)0.740 (15.0)0.164 (10.5)
K46 (minutes−1)0.50.5
Q (mL/minutes )0.930.93
f u 0.80.8
Vv (mL)0.160.16
Vif (mL)0.620.62
Vic (mL)0.780.78
  • * Values in parenthesis indicate % coefficient of variation of parameter estimate obtained by weighted least-squares regression.