Table 2

Model parameters for human hybrid pharmacokinetic models for carboplatin and topotecan

ParametersCarboplatinTopotecan
K01 (minutes−1)0.015 (7.9) *0.022 (7.9)
K12 (minutes−1)0.011 (39.8)0.010 (6.6)
K21 (minutes−1)0.018 (78.2)0.025 (12)
K34 (minutes−1)0.027 (26.4)0.013 (27)
K43 (minutes−1)0.011 (26.6)0.043 (29)
V1 (L)9.59 (7.2)42.0 (9.6)
  • * Values represent mean (% coefficient of variation) of model-fitted estimates from simulated error datasets (N = 200) for each drug.