Model parameters for human hybrid pharmacokinetic models for carboplatin and topotecan
| Parameters | Carboplatin | Topotecan |
|---|---|---|
| K01 (minutes−1) | 0.015 (7.9) * | 0.022 (7.9) |
| K12 (minutes−1) | 0.011 (39.8) | 0.010 (6.6) |
| K21 (minutes−1) | 0.018 (78.2) | 0.025 (12) |
| K34 (minutes−1) | 0.027 (26.4) | 0.013 (27) |
| K43 (minutes−1) | 0.011 (26.6) | 0.043 (29) |
| V1 (L) | 9.59 (7.2) | 42.0 (9.6) |
* Values represent mean (% coefficient of variation) of model-fitted estimates from simulated error datasets (N = 200) for each drug.