Table 3

Patterns of aneusomy in each dormancy candidate who had a CTC

Patient no.First blood sampleTime between first and second sample (mo)Second blood sampleTime between first and third sample (mo)Third blood sample
No. of CTCsBlood volume (mL)Aneusomic pattern*No. of CTCsBlood volume (mL)Aneusomic pattern*No. of CTCsBlood volume (mL)Aneusomic pattern*
Initially positive
6212.51x(4,3,2) 1x(3,2,2)8.52251x(3,3,2) (2,3) 1x(4,1,3) (2,3)20.11251x(2,3,3)
13212.52x(3,4,3,)31251x(5,1,2)7.81251x(2,3,3) (3,2)
7112.51x(4,3,5)9015
12112.51x(5,3,4)9.51151x(5.3.4)
31251x(2,2,4) (3,3)41151x(2,2,4)
42251x(3,2,3) (4,2) 1x(2,3,3) (2,2)
51101x(2,3,2) (3,3)61251x(2,2,3) (3,2)14.2025
82151x(1,1,2) (2,2) 1x(2,2,2) (2,4)31151x(1,1,2)8.84501x(4,3,5); 1x(2,2,4) 1x(5,2,5); 1x(3,2,3)
91151x(2,3,2) (3,3)
102251x(1,2,5) 1x(3,3,2) (3,2)
112251x(2,2,5) 1x(2,2,4) (4,2)
Initially negative
1012.51.5212.51x(2,2,3) 1x(2,3,3)
2012.52.5112.51x(3,2,3)9.52151x(2,3,1);
1x(2,2,3)
14012.513015
150253015
36012.512015
20012.52.5012.5
  • * All cells were probed for chromosomes 1, 8, and 17. Some cells were reprobed for chromosomes 3 and 11. x = number of CTCs. The parentheses containing three numerals represent copy number of CEP 1, 8, and 17, respectively. The parentheses containing two numerals represent copy number of CEP 3 and 11, respectively.

  • Only a portion of patients has been drawn more than once to date.