Table 6

Effects of known FMO3 polymorphisms on substrate affinity

PolymorphismsSubstratesReferences
E158K Trimethylamine 24 , 32 , 35
E158K and E308GTrimethylamine 34
E158K and E308GRanitidine and thiobenzamide 36
E308G Methimazole 37
E158K, E308G, and V257MClonazpine and caffeine 25
E158K Benzydamine 38