Table 1

Salivary mRNA up-regulated (>3-fold, P < 0.01) in OSCC identified by microarray

Gene symbolGene nameGenBank accession no.LocusGene functions
B2M β-2-microglobulinNM_0404815q21-q22.2Antiapoptosis; antigen presentation
DUSP1 Dual specificity phosphatase 1NM_044175q34Protein modification; signal transduction; oxidative stress
FTH1 Ferritin, heavy polypeptide 1NM_0203211q13Iron ion transport; cell proliferation
G0S2 Putative lymphocyte G0-G1 switch geneNM_0157141q32.2-q41Cell growth and/or maintenance; regulation of cell cycle
GADD45B Growth arrest and DNA-damage-inducible, βNM_01567519p13.3Kinase cascade; apoptosis
H3F3A H3 histone, family 3ABE8699221q41DNA binding activity
HSPC016 Hypothetical protein HSPC016BG1675223p21.31Unknown
IER3 Immediate early response 3NM_0038976p21.3Embryogenesis; morphogenesis; apoptosis; cell growth and maintenance
IL1B Interleukin 1, βM153302q14Signal transduction; proliferation; inflammation; apoptosis
IL8 Interleukin 8NM_0005844q13-q21Angiogenesis; replication; calcium-mediated signaling pathway; cell adhesion; chemotaxis; cell cycle arrest; immune response
MAP2K3 Mitogen-activated protein kinase kinase 3AA78038117q11.2Signal transduction; protein modification
OAZ1 Ornithine decarboxylase antizyme 1D8791419p13.3Polyamine biosynthesis
PRG1 Proteoglycan 1, secretory granuleNM_00272710q22.1Proteoglycan
RGS2 Regulator of G-protein signaling 2, 24 kdaNM_0029231q31Oncogenesis; G-protein signal transduction
S100P S100 calcium binding protein PNM_0059804p16Protein binding; calcium ion binding
SAT Spermidine/spermine N1-acetyltransferaseNM_002970Xp22.1Enzyme, transferase activity
EST, highly similar ferritin light chainBG537190Iron ion homeostasis, ferritin complex
  • NOTE. The human Genome U133A microarrays were used to identify the difference in RNA expression patterns in saliva from 10 cancer patients and 10 matched normal subjects. Using a criteria of a change in regulation >3-fold in all 10 OSCC saliva specimens and a cutoff of P value < 0.01, we identified 17 mRNA, showing significant up-regulation in OSCC saliva.