Table 2

SIBLING expression in different cancer types

Breast cancerUterine cancerColon cancerStomach cancerOvarian cancerLung cancerRectal cancerThyroid cancerKidney cancer
BSP
t test*YesNoYesYesNoNoYesYesYes
 >m + 2 SDYesNoYesYesYesYesYesYesYes
 Other studies (ref. no.)4 and 28 29 7 8
OPN
t test*YesYesYesNoYesYesYesYesNo
 >m + 2 SDYesYesYesYesYesYesYesNoNo
 Other studies (ref. no.)30 and 3132 and 3334 and 3536 and 3738 and 39 40 2
DMP1
t test*YesYesYesNoNoYesNoNoNo
 >m + 2 SDYesNoNoNoNoYesNoNoNo
 Other studies (ref. no.) 9
DSPP
t test*YesNoNoNoNoYesNoNoNo
 >m + 2 SDNoNoNoNoNoYesNoNoNo
 Other studies (ref. no.)
  • * Significant elevation defined by a paired t test pairing individual subject’s normal and tumor tissue expression levels.

  • Significant elevation defined by a mean cancer tissue level of expression >m + 2SD.

  • Published studies finding increased expression of SIBLINGs in a given tumor type.