Table 1

Comparison of drug sensitivity among Calu3 parental cells and cells derived from paclitaxel resistance and combination (mean ± SD, n = 3 from three separate experiments)

CellsPaclitaxel RFVincristine RFDoxorubicin RFCisplatin RF
Parental cells1111
Paclitaxel alone26.0 ± 1.325.7 ± 2.06.8 ± 2.01.0 ± 0.1
Combination1.0 ± 0.20.9 ± 0.10.9 ± 0.20.9 ± 0.1
  • NOTE. Cells were treated with paclitaxel, vincristine, doxorubicin, and cisplatin at various concentrations for 3 days. Drug effects were measured by MTT assay. IC50, the concentration needed to inhibit 50% of cell growth for each drug was determined. The ratio of IC50 of resistant variant to that of parent cells was expressed as resistant factor (RF).