Table 2

Multivariate analysis of prognostic factors

Prognostic factorsModel 1 (HIF2)aModel 2 (HIF1–HIF2)
χPχP
Dukes stage8.37<0.016.80<0.01
HIF2 expression2.44NS
HIF1–HIF2 expression5.33<0.05
Age0.25NS0.364NS
Sex0.40NS0.08NS
Tumor differentiation0.48NS0.90NS
Tumor size1.67NS0.63NS
Lymphatic invasion0.02NS0.02NS
Tumor location0.10NS0.10NS
  • a HIF2, hypoxia-inducible factor 2α; HIF1, hypoxia-inducible factor 1α; HIF1–HIF2, combination of HIF-1α and HIF-2α; NS, not significant.