Table 5

Correlation of standard central sample with various samples taken from the same tumor

PCR-RFLP result in standard central sampleNo. of patientsAgreement with additional tumor samples: no. confirmed/no. analyzed (estimated percentage of tumor heterogeneity).
4/4 (0)3/3b (0)2/2c (0)3/4 (20d)2/4 (40e)
Mutateda860101
Wild-type1081010
• a Only K-ras codon 12 mutations.

• b From 1 patient only 3 additional tumor samples were analyzed.

• c From 1 patient only 2 additional tumor samples were analyzed.

• d One of 5 tumor sample was found to be mutated; this corresponds to a heterogeneity of 20%.

• e Two of 5 tumor samples were found to be wild-type; this corresponds to a heterogeneity of 40%.