Table 5

Cell growth inhibition by cisplatin in the presence or absence of AG14361

Cell linesGI50 Cis Pt (μm)aPF50
Cis Pt aloneCis Pt + AG14361
A27800.72 ± 0.05b0.70 ± 0.07 0.98 ± 0.13
CP704.8 ± 2.84.7 ± 2.7 0.96 ± 0.1
Resistance factor 6.7 ± 3.7 c 6.5 ± 3.5 c
CP70-ch38.0 ± 4.88.8 ± 3.9 1.4 ± 0.8
CP70-ch212.3 ± 612.2 ± 6.0 0.99 ± 0.11
Resistance factor 1.8 ± 0.8 1.4 ± 0.5
  • a GI50 is the concentration of cisplatin (Cis Pt) ± 400 nm AG14361 required to inhibit growth by 50% after 5 days of continuous exposure.

  • b Data are mean ± SD of four independent experiments.

  • c Significant resistance (P < 0.05: unpaired Student’s t test).