Table 4

Immunohistochemical analysis of tumors from paclitaxel-sensitive human ovarian cancer cells SKOV3ip1 and Hey A8 growing in the peritoneal cavity of nude mice

Treatment groupCD31aProliferating cell nuclear antigenaTumor cellsEndothelial cells
TUNEL+a% TUNEL+b
Control46 ± 8110 ± 1210 ± 40
Paclitaxel28 ± 7c65 ± 16c39 ± 15c1
STI57142 ± 6106 ± 912 ± 70
Paclitaxel+ STI57115 ± 5d35 ± 8d49 ± 17c10d
  • a Mean ± SD positive cells/field determined from quantitation in 10 random 0.159-mm2 fields at ×100 magnification.

  • b Percentage of CD31+ terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL)+ cells in 10 random 0.011-mm2 fields at ×400 magnification.

  • c P < 0.01 compared with control and STI571 alone.

  • d P < 0.05 compared with all other groups, including paclitaxel alone.