Table 5

Immunohistochemical analysis of tumors from paclitaxel-resistant Hey A8 human ovarian cancer cells growing in the peritoneal cavity of nude mice

Treatment groupCD31aProliferating cell nuclear antigenaTumor cellsEndothelial cells
TUNEL+a% TUNEL+b
Control48 ± 7106 ± 89 ± 40
Paclitaxel44 ± 699 ± 1011 ± 61
STI57146 ± 5104 ± 910 ± 51
Paclitaxel+ STI57121 ± 7c47 ± 11c37 ± 16d9c
  • a Mean ± SD positive cells/field determined from quantitation in 10 random 0.159-mm2 fields at ×100 magnification.

  • b Percentage of CD31+ terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL)+ cells in 10 random 0.011-mm2 fields at ×400 magnification.

  • c P < 0.05 compared with all other groups.