Table 2

Dose levels and dose-limiting toxicities (DLTs)

Dose levelIrinotecan dose (mg/m2/day)No. of patientsNo. of DLTsType of DLT
I20.03 + 3a0None
II25.064Grade 3–4 diarrhea
III22.542Grade 3 diarrhea
  • a Three additional patients initially treated at the II or III dose level of irinotecan received additional treatment at 20.0 mg/m2/day after dose reduction for diarrhea.