Table 5

Plasma pharmacokinetics of irinotecan, SN-38, and SN-38 glucuronide normalized to the dose of 22.5 mg/m2/day.

Data are mean ± SD.

Area under the time-concentration curve0–170 hxμmol/literSteady-state concentrations nmol/literPeak plasma concentration nmol/literClearance liter/h/m2
Irinotecan7.03 ± 0.4742.7 ± 25.260.5 ± 21.345.3 ± 26.7
SN-381.96 ± 0.2614.88 ± 1.8517.9 ± 1.4
SN-38 glucuronide4.35 ± 0.5031.72 ± 3.4743.9 ± 0.4