Table 6

Area under the time-concentration curve (AUC) of SN-38 after administration of irinotecan by short or prolonged infusions

Dose regimenDose intensity (mg/m2/week)SN-38 AUC (nmol/liter × h)Reference
Irinotecan administered as prolonged i.v. infusion
22.5 mg/m2/day × 7 day every 3 wk52.51920 ± 300a
12.5 mg/m2/day × 14 day every 3 wk58.52500 ± 1200a 16
12.5 mg/m2/day × 4 day × 2 wk every 3 wk33.3769 ± 368a 15
Irinotecan administered as 1-h i.v. infusion
150 mg/m2 every 3 wk50275 ± 69b 19
300 mg/m2 every 3 wk100484 ± 132b 19
  • a Mean ± SD.

  • b Mean ± SE.