Table 3

Nonhematologic toxicity

Adverse effectNo. of patientsa
Level 1 (n = 3)Level 2 (n = 6)Level 3 (n = 6)Level 4 (n = 3)Level 5 (n = 5)
Appetite loss
 Grade 1, 222322
 Grade 300 + 1b002
 Grade 400000
Nausea/Vomiting
 Grade 1, 224403
 Grade 300000
 Grade 400000
Stomatitis
 Grade 1, 212000
 Grade 300000
 Grade 400000
Diarrhea
 Grade 1, 203300
 Grade 300000
 Grade 401 + 1b000
Skin
 Grade 1, 201101
 Grade 30000 + 1c0
 Grade 400000
General fatigue
 Grade 1, 213112
 Grade 300000
 Grade 400000
Hepatotoxicity
 Grade 1, 223432
 Grade 301000
 Grade 400000
Nephrotoxicity
 Grade 1, 205201
 Grade 300000
 Grade 400000
  • a 1, 2, 3, 4, 6 mg/m2 of cisplatin with 80 mg/m2 of S-1 were given at Level 1, 2, 3, 4, 5, respectively.

  • b Due to influenza.

  • c Due to dermatomyositis.