Table 4

Dose limiting toxicity

Adverse effectNo. of patientsa
Level 1 (n = 3)Level 2 (n = 6)Level 3 (n = 6)Level 4 (n = 3)Level 5 (n = 5)
Total patients no. of DLTb02003
Leukopenia01000
Neutropenia01001
Anemia00000
Thrombocytopenia01000
Appetite loss00002
Diarrhea01000
Stomatitis00000
Skin toxocity00000
Hepatotoxicity01000
Nephrotoxicity00000
  • a 1, 2, 3, 4, 6 mg/m2 of cisplatin with 80 mg/m2 of S-1 were given at Level 1, 2, 3, 4, 5, respectively.

  • b DLT, dose limiting toxicity.