Table 5

Relationship between expression of ABCa transporter proteins and response to chemotherapy or survival (n = 72)

nResponse rate (%)PPFS (mo)PMST (mo)P
Pgp
 Positive25320.724.60.4513.20.89
 Negative47364.210.2
MRP1
 Positive56340.794.20.919.60.39
 Negative16384.214.2
MRP2
 Positive12420.573.10.105.40.002
 Negative60334.513.2
MRP3
 Positive1043>0.994.70.5913.20.93
 Negative62364.29.6
BCRP
 Positive33240.082.80.00036.80.004
 Negative39445.115.2
  • a ABC, ATP-binding cassette; PFS, progression-free survival; MST, median survival time; Pgp, P-glycoprotein; MRP, multidrug resistance protein.